Creatine, typically used to enhance muscle performance, is being explored for its potential to improve brain energy and alleviate depression symptoms. A recent review examined five randomized clinical trials involving 238 participants assessing creatine's impact on depression.
The results were mixed. Two trials reported symptom improvements in women with major depressive disorder when creatine was added to conventional treatments. However, three other studies found no significant benefits.
These findings suggest creatine may help some individuals with depression, particularly women, but further research is needed to confirm efficacy and understand mechanisms.
